[CK] Melatonin - started with 0.5 to 1 mg

Dosing —preparations providing 0.3 to 0.5 mg(1.0 mg pills in half).
     Start with physiologic dose. Esp. elderly = lower dose like 1 or 0.5 ! 


Although melatonin is relatively nontoxic, some marketed doses (1 to 10 mg) can elevate plasma concentrations to 3 to 60 times their normal peak values (figure 3) [54]. Supraphysiologic concentrations of melatonin produce numerous biological effects, including daytime sleepiness, impaired mental and physical performance [73], hypothermia [26], and hyperprolactinemia [74]. These effects are not observed with physiologic concentrations of melatonin.