COVID-19[ ]

(1) Epidemiological concept

(2) Pathophysiology concept

(3) Clinical sign
; fever + URI(cough, sore throat) ~ LRI(pneumonia) ~ death.

= Testing indication(PUI);
fever 
and/or LRI symptom (CXR - infiltration ) = BUT it might not be found. 

AND

exposure(COVID 19 -confirmed or suspected ; or traveled outside; ) in 14days prior.
(confirmed, suspected, residence, potential - in the event..)

OR
unknown cause of LRI

(4) Dx. kit
; how long does it take? PCR kit. Where to get? How to run? 
= it will take 3-4 days to come back(NC)

; other respiratory pathogens, upper respiratory tract (nasopharyngeal and oropharyngeal swab) specimens and, if possible, lower respiratory tract specimens

(5) Tx.
- Precaution: airborne precaution(Standard, Droplet; mostly droplet though)
Contacting PUI; for sure
Current policy? => notify state, infectious disease(infection control) 
My policy?

DECISION to DISCONTINUE quarantine. 
Appropriate notification: When COVID-19 is suspected, infection control measures should be implemented and public health officials notified.

Discontinue: resolution of clinical signs and symptoms and negative results of reverse-transcription polymerase chain reaction (RT-PCR) testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on two sequential paired nasopharyngeal and throat specimens (ie, four specimens total, each handled separately), with each pair collected ≥24 hours apart [82].

Positive RT-PCR tests for SARS-CoV-2 were reported in four laboratory-confirmed COVID-19 patients after they had clinically improved and tested negative on two consecutive tests [83]. The clinical significance of this finding is uncertain; it is unknown whether these individuals continued to shed infectious virus.

- Conservative management.
- Chloroquine: